Granulation Methods

Roll Compaction Granulation

Characteristics of Roll Compaction Granulation

Produces dense, irregular shaped granule
Dry granulation – No liquids involved
Continuous process
Fines generated by process can be recycled

High Shear Granulation

Characteristics of High Shear Granulation

Produces very dense, irregular shaped granule
Very fast and simple process
Requires drying method (ex. fluid bed or vacuum drying)
Wider particle size variation compared to other methods

Top Spray Granulation

Characteristics of Top Spray Granulation

Produces less dense, more uniform granule
Easy set-up, quick changeover between batches
Rapidly disintegrating granules due to increased surface area
Multi-functional granulator (also used for Drying and Coating Processes)
Increased batch volumes (up to 8,400 L)

Rotor Granulation (Spheronization)

Characteristics of Rotor Granulation (Spheronization)

Produces very dense, spherical granule – for superior flow characteristics
Most uniform product size and active drug distribution
Processes are shortened by introducing drying air methods (Granurex) Produces very dense, irregular shaped granule